1430475-44-7

Upstream product

• 1071656-38-6 2-cyclohexyl-1-(naphthalen-2-yl)ethan-1-one 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 66-99-9 β-naphthaldehyde 
• 2243-83-6 2-naphthaloyl chloride 
• 2550-36-9 Cyclohexylmethyl bromide 

Downstream Products

• 1430475-55-0 C₂₁H₂₆O₂ 
• 1442650-07-8 (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-(benzoylthio)-2-methylpropanoate 
• 1442650-08-9 (R)-2-cyclohexyl-1-(naphthalen-2-yl)ethyl 2-mercapto-2-methylpropanoate 
• 1442650-09-0 (S)-2-(1-cyclohexylbutan-2-yl)naphthalene 
• 1606160-73-9 (S)-2-(2-cyclohexyl-1-methoxyethyl)naphthalene 
• 1606160-90-0 (+)-2-(1-cyclohexylpentan-2-yl)naphthalene 
• 1606160-91-1 (+)-2-(1-cyclohexylheptan-2-yl)naphthalene 
• 1606160-93-3 (+)-2-(1-cyclohexyl-7-methyloct-6-en-2-yl)naphthalene 
• 1606160-94-4 (+)-2-(1-cyclohexyl-6,6,6-trifluorohexan-2-yl)naphthalene 
• 1606160-95-5 (+)-2-(1-cyclohexyl-4-methylpentan-2-yl)naphthalene 
• 1606161-00-5 (-)-2-(2-cyclohexyl-1-phenylethyl)naphthalene 
• 1606161-01-6 (-)-4-(2-cyclohexyl-1-(naphthalen-2-yl)ethyl)-N,N-dimethylaniline 
• 1606161-02-7 (-)-2-(2-cyclohexyl-1-(4-methoxyphenyl)ethyl)naphthalene 
• 1606161-03-8 (-)-2-(2-cyclohexyl-1-(4-fluorophenyl)ethyl)naphthalene 

Relevant academic research and scientific papers

Nickel-Mediated Enantiospecific Silylation via Benzylic C-OMe Bond Cleavage

Benzylic stereocenters are found in bioactive and drug molecules, as enantiopure benzylic alcohols have been used to build such a stereogenic center, but are limited to the construction of a C-C bond. Silylation of alkyl alcohols has the potential to build bioactive molecules and building blocks; however, the development of such a process is challenging and unknown. Herein, we describe an unprecedented AgF-assisted nickel catalysis in the enantiospecific silylation of benzylic ethers.

Stereospecific nickel-catalyzed cross-coupling reactions of alkyl grignard reagents and identification of selective anti-breast-cancer agents

Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp 3)-C(sp3) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Sev

Functional-group-tolerant, nickel-catalyzed cross-coupling reaction for enantioselective construction of tertiary methyl-bearing stereocenters

The first Negishi nickel-catalyzed stereospecific cross-coupling reaction of secondary benzylic esters is reported. A series of traceless directing groups is evaluated for ability to promote cross-coupling with dimethylzinc. Esters with a chelating thioether derived from commercially available 2-(methylthio)acetic acid are most effective. The products are formed in high yield and with excellent stereospecificity. A variety of functional groups are tolerated in the reaction including alkenes, alkynes, esters, amines, imides, and O-, S-, and N-heterocycles. The utility of this transformation is highlighted in the enantioselective synthesis of a retinoic acid receptor agonist and a fatty acid amide hydrolase inhibitor.