14305-99-8Relevant academic research and scientific papers
FGF receptor on a 4,6-dimethyl-Oxazolo [5,4-d] pyrimidine -5,7 (4H, 6H)-dione derivatives
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Paragraph 0048, (2016/10/08)
The invention discloses a 4,6-dimethyl-oxazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione derivative acting on a fibroblast growth factor (FGF) receptor. A target compound is prepared by implementing nitrosation on 1,3-dimethyl pyrimidine-2,4,6(1H,3H,5H)-trione which serves as a starting material through NaNO2, reducing the material through Na2S2O4, implementing a Schiff alkali reaction with aromatic aldehyde, and finally cyclizing through SOCl2. The 4,6-dimethyl-oxazolo[5,4-d]pyrimidine-5,7(4H,6H)-dione derivative disclosed by the invention has a certain inhibiting function on experimental cells and shows a certain antitumor activity. For an H460 cell, IC50 values of compounds N5a, N5g and N5k are less than that of a positive control drug; for a B16F10 cell, IC50 values of compounds N5f, N5h and N5i are less than IC50 value of the positive control drug; for an A549 cell, IC50 value of the positive control is relatively high, and IC50 values of compounds N5f, N5g, N5h and N5l are less than IC50 value of the positive control drug.
Nitration of 2-substituted pyrimidine-4,6-diones, structure and reactivity of 5,5-gem-dinitropyrimidine-4,6-diones
Langlet, Abraham,Latypov, Nikolaj V.,Wellmar, Ulf,Bemm, Ulf,Goede, Patrick,Bergman, Jan,Romero, Ivan
, p. 7833 - 7838 (2007/10/03)
Nitration of some 2-substituted pyrimidine-4,6-diones in sulfuric acid was studied, which afforded previously unknown 5,5-gem-dinitropyrimidine-4,6-diones in high yields. The gem-dinitro products were easily attacked by nucleophiles with concomitant formation of gem-dinitroacetyl derivatives, which in turn could be further hydrolyzed to salts of dinitromethane and triureas.
Gas/Solid Reactions with Nitrogen Dioxide
Kaupp, Gerd,Schmeyers, Jens
, p. 5494 - 5503 (2007/10/02)
Numerous gas/solid reactions of nitrogen dioxide with organic substrates are investigated preparatively and mechanistically.Gaseous NO2 reacts with crystalline stable free radicals (nitroxyls 1, verdazyl 6) by electron transfer.The nitrite ions formed are irreversibly oxidized by NO2 via oxygen atom transfer.Solid cation nitrates are formed quantitatively.Thione bonds of thiohydantoins 8 are transformed to carbonyl bonds with formation of sulfur and NO presumably via nitrites as intermediates.Hydantoin 13 oxygenates at its free 5-methylene group via C-H abstraction and nitrite or it undergoes N-1 nitration via N-H abstraction depending on the conditions.Both reactions proceed quantitatively. 1,3-Oxazolidin-2-one (15) gives N-nitration and N-nitrosation with the NO produced.Nonenolized crystalline barbituric acids 17 are quantitatively nitrated (C-N bond formation with radicals) at their methylene groups. 4-Hydroxybenzaldehyde (19) and vanilline (22) give quantitative aromatic nitration (C-N bond formation with arenes) without melting.All possible regioisomers are formed.Solid 9-methylanthracene (26) gives a quantitative yield of its 10-nitro derivative 27.Crystalline anthracene (28) and gaseous NO2 yield 3 primary products 29 (cis; trans) and the new dimeric product 30 as well as the stable secondary products 31 and 32.The gas/solid tetranitration of tetraphenylethylene (33) is severely hindered by the water of reaction.However, a 95percent yield of pure tetrakis(p-nitrophenyl)ethylene is obtained if the drying agent MgSO4*2H2O is admixed and the product 34 extracted.The gas/solid procedures avoid solvents and fuming nitric acid.They give pure products without necessity for recrystallization in most cases and they avoid wastes.Atomic force microscopy (AFM) measurements on prominent faces of single crystals of 1a, 11a, 28, and 33 reveal phase rebuildings with well-directed long-range molecular transport.Nanoliquids were only present on (110) of 28.The characteristic AFM features are correlated with known X-ray crystal structure data and compared with previous results.The shape of the features depends on the molecular packing in the crystal bulk and on the molecular shapes.Molecular interpretations of the AFM features are given.
