1430563-91-9

Usage

Chemical class

Tetrahydroisoquinolines

Carboxylic acid group

Presence of a carboxyl functional group (-COOH)

Tert-butoxycarbonyl protecting group

A protecting group (-OC(CH3)3) attached to the carbonyl group, which can be removed under certain conditions

Bromine atom

A bromine atom (Br) attached to the aromatic ring, which can be used for further derivatization or modification

Potential pharmaceutical applications

Use in the synthesis of various pharmaceutical drugs

Unique structure and reactivity

Valuable building block for the creation of new and potentially beneficial molecules

Range of related compounds

Presence of the bromine atom allows for the creation of a range of related compounds with potentially different properties and biological activities

Upstream product

• 1109230-24-1 methyl 2-(2-bromophenyl)ethylcarbamate 
• 65185-58-2 2-(2-bromophenyl)ethanamine 
• 1430563-90-8 5-bromo-2-(methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1430564-17-2 methyl 5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylate 
• 140202-12-6 5-bromo-2-(ethoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 1430563-92-0 5-bromo-2-(tert-butoxycarbonyl)-3,4-dihydroisoquinoline-1-carboxylic acid methyl ester 
• 1391006-26-0 5-bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Downstream Products

• 1430563-97-5 5-bromo-1-((4-(tert-butoxycarbonyl)phenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-carboxylic acid tert-butyl ester 
• 1430563-87-3 tert-butyl 1-(4-carbamoylphenylcarbamoyl)-5-(pyridin-2-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430562-69-8 (E)-N-(4-carbamoylphenyl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(pyridin-2-yloxy)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide 
• 1430562-76-7 (E)-4-(5-(1-acetylpiperidin-4-yl)-2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 
• 1430563-96-4 tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1430562-78-9 (E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430564-26-3 4-(5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430562-93-8 (S,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430562-97-2 (R,E)-4-(2-(3-(6-acetyl-3-chloro-2-fluorophenyl)acryloyl)-5-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430562-95-0 (E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(1-methylpiperidin-4-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430563-30-6 (R,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(1-methylpiperidin-4-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430563-32-8 (S,E)-4-(2-(3-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(1-methylpiperidin-4-yl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid trifluoroacetate salt 
• 1430564-12-7 2-tert-butyl 1-methyl 5-(4-(methylcarbamoyl)phenyl)-3,4-dihydroisoquinoline-1,2(1H)-dicarboxylate 
• 1430564-13-8 2-(tert-butoxycarbonyl)-5-(4-(methylcarbamoyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 

Relevant academic research and scientific papers

Tetrahydroisoquinoline amide compounds containing quaternary ammonium ion and pharmaceutical use thereof

The invention relates to tetrahydroisoquinoline amide compounds containing quaternary ammonium ion, a preparation method of the compounds, and a use of the compounds in the treatment or prevention ofthromboembolic diseases.

Tetrahydroisoquinoline compound and its preparation method, pharmaceutical composition and use

The invention relates to a tetrahydroisoquinoline compound and its preparation method, pharmaceutical composition and use. The tetrahydroisoquinoline compound is shown by the general formula (1). In the general formula (1), the symbols have the same definitions as in the specification.

GUANIDINE AND AMINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): (Formula (I)) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

GUANIDINE SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be us

TETRAHYDROISOQUINOLINES CONTAINING SUBSTITUTED AZOLES AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I) or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.