1430657-59-2Relevant academic research and scientific papers
Synthesis and in vitro evaluation of a PDT active BODIPY-NLS conjugate
Verwilst, Peter,David, Charlotte C.,Leen, Volker,Hofkens, Johan,De Witte, Peter A.M.,De Borggraeve, Wim M.
, p. 3204 - 3207 (2013)
Two new photosensitizers based on the BODIPY scaffold have been synthesized, of which one bears an NLS peptide, which is linked to the BODIPY's core using the copper catalysed azide-alkyne click reaction. The phototoxicities of these BODIPY based photosensitizers have been determined, as well as their dark toxicities. Although the conjugation of a single NLS peptide to the BODIPY did not lead to any observable nuclear localization, the photosensitizer did exhibit a superior photoxicity. Cellular co-localization experiments revealed a localization of both dyes in the lysosomes, as well as a partial localization within the ER (for the peptide-bearing BODIPY).
