6367-36-8

Basic information

• Product Name: tert-butyl azidoacetate
• Synonyms: 2-Methyl-2-propanyl azidoacetate; acetic acid, 2-azido-, 1,1-dimethylethyl ester; Acetic acid, azido-, 1,1-dimethylethyl ester; tert-Butyl azidoacetate
• CAS NO: 6367-36-8
• Molecular Formula: C₆H₁₁N₃O₂
• Molecular Weight: 157.1704
• Mol File: 6367-36-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: tert-butyl azidoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl azidoacetate(6367-36-8)
• EPA Substance Registry System: tert-butyl azidoacetate(6367-36-8)

Safety Data

• Hazardous Substances Data: 6367-36-8(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 107-59-5 tert-Butyl chloroacetate 

Downstream Products

• 6456-74-2 Glycine tert-butyl ester 
• 111652-20-1 N-(tert-butoxycarbonyl)glycine tert-butyl ester 
• 24513-05-1 ethyl (Z)-2-azido-3-(4-chlorophenyl)acrylate 
• 250213-45-7 tert-butyl 2-azido-3-(4-chlorophenyl)-3-hydroxypropionate 
• 1000682-50-7 C₁₅H₁₇N₃O₂ 
• 1233345-75-9 4-(3-acetamidophenoxy)methyl-1-(tert-butyloxycarbonyl)methyl-1H-1,2,3-triazole 
• 1233345-77-1 1-(tert-butyloxycarbonyl)methyl-4-(p-toluenesulfonamido)methyl-1H-1,2,3-triazole 
• 1233345-73-7 1-(tert-butyloxycarbonyl)methyl-4-phenyl-1H-1,2,3-triazole 
• 1233345-74-8 4-(benzamido)methyl-1-(tert-butyloxycarbonyl)methyl-1H-1,2,3-triazole 
• 1337908-28-7 2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester 
• 189808-70-6 tert-butyl 2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}acetate 

Relevant articles and documents

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

Chemotherapy-induced neurotoxicity is a common adverse effect of cancer treatment. No medication has been shown to be effective in the prevention or treatment of chemotherapy-induced neurotoxicity. Using minoxidil as an initial template for structural modifications in conjunction with an in vitro neurite outgrowth assay, an image-based high-content screening platform, and mouse behavior models, an effective neuroprotective agent CN016 was discovered. Our results showed that CN016 could inhibit paclitaxel-induced inflammatory responses and infiltration of immune cells into sensory neurons significantly. Thus, the suppression of proinflammatory factors elucidates, in part, the mechanism of action of CN016 on alleviating paclitaxel-induced peripheral neuropathy. Based on excellent efficacy in improving behavioral functions, high safety profiles (MTD > 500 mg/kg), and a large therapeutic window (MTD/MED > 50) in mice, CN016 might have great potential to become a peripherally neuroprotective agent to prevent neurotoxicity caused by chemotherapeutics as typified by paclitaxel.

Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization

Herein, we report a metal-free synthesis of cyclic amidines, oxazines, and an oxazinone under mild conditions by electrophilic amide activation. This strategy features an unusual Umpolung cyclization mode and enables the smooth union of α-aryl amides and diverse alkylazides, effectively rerouting our previously reported α-amination transform.

ZWITTERIONICALLY MODIFIED POLYMERS AND HYDROGELS

The present invention is directed to a polymer of Formula (IV): wherein A, X, Q, Y, Z, m1; m2, m3, k1; and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III), wherein R", X1, Y1, Z1, m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.