14307-90-5

Basic information

• Product Name: N,N-diethyl-2-(phenylamino)acetamide
• Synonyms: N,N-diethyl-2-(phenylamino)acetamide;2-Anilino-N,N-diethylacetamide;PC-26
• CAS NO: 14307-90-5
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.2841
• Mol File: 14307-90-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 362.3°Cat760mmHg
• Flash Point: 172.9°C
• Appearance: /
• Density: 1.053g/cm³
• Vapor Pressure: 1.95E-05mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: N,N-diethyl-2-(phenylamino)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-(phenylamino)acetamide(14307-90-5)
• EPA Substance Registry System: N,N-diethyl-2-(phenylamino)acetamide(14307-90-5)

Safety Data

• Hazardous Substances Data: 14307-90-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H18N2O/c1-3-14(4-2)12(15)10-13-11-8-6-5-7-9-11/h5-9,13H,3-4,10H2,1-2H3

Upstream product

• 62-53-3 aniline 
• 2315-36-8 2-Chloro-N,N-diethylacetamide 
• 6112-00-1 N,N-diethyl-2-diazoacetamide 

Downstream Products

• 106321-35-1 N-chloroacetyl-N-phenyl-glycine diethylamide 
• 102440-56-2 N-(2-hydroxy-ethyl)-N-phenyl-glycine diethylamide 
• 101779-68-4 phenylimino-di-acetic acid bis-diethylamide 
• 100876-32-2 N-(diethylcarbamoyl-methyl)-N-phenyl-glycine 
• 92699-33-7 N-phenyl-N-propionyl-glycine diethylamide 
• 94309-07-6 N-Phenyl-N-benzoyl-aminoessigsaeure-diaethylamid 

Relevant articles and documents

Cytochrome P450-catalyzed insertion of carbenoids into N-H bonds

Expanding nature's catalytic repertoire to include reactions important in synthetic chemistry will open new opportunities for 'green' chemistry and biosynthesis. We demonstrate the first enzyme-catalyzed insertion of carbenoids into N-H bonds. This type of bond disconnection, which has no counterpart in nature, can be mediated by variants of the cytochrome P450 from Bacillus megaterium. The N-H insertion reaction takes place in water, provides the desired products in 26-83% yield, forms the single addition product exclusively, and does not require slow addition of the diazo component.