1430847-87-2

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 58905-19-4 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone 
• 29941-90-0 Brenzcatechinmonocyclopentylaether 
• 1360599-76-3 toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester 

Relevant academic research and scientific papers

Plant growth regulator

PROBLEM TO BE SOLVED: To provide a specific inhibitor of brassinosteroid biosynthesis.SOLUTION: The plant growth regulator includes a compound represented by formula (I) (wherein, Rand Rdenote a hydrogen atom or the like; Rand Rdenote a phenyl group which

Synthesis and biological evaluation of novel azole derivatives as selective potent inhibitors of brassinosteroid biosynthesis

Brassinosteroids (BRs) are phytohormones that control several important agronomic traits, such as flowering, plant architecture, seed yield, and stress tolerance. To manipulate the BR levels in plant tissues using specific inhibitors of BR biosynthesis, a series of novel azole derivatives were synthesized and their inhibitory activity on BR biosynthesis was investigated. Structure-activity relationship studies revealed that 2RS, 4RS-1-[4-(2- allyloxyphenoxymethyl)-2-(4-chlorophenyl)-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4] triazole (G2) is a highly selective inhibitor of BR biosynthesis, with an IC50 value of approximately 46 ± 2 nM, which is the most potent BR biosynthesis inhibitor observed to date. Use of gibberellin (GA) biosynthesis mutants and BR signaling mutants to analyze the mechanism of action of this synthetic series indicated that the primary site of action is BR biosynthesis. Experiments feeding BR biosynthesis intermediates to chemically treated Arabidopsis seedlings suggested that the target sites of this synthetic series are CYP90s, which are responsible for the C-22 and/or C-23 hydroxylation of campesterol.