1360599-76-3

Basic information

• Product Name: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester
• Synonyms: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester
• CAS NO: 1360599-76-3
• Molecular Weight: 449.915
• Mol File: 1360599-76-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester(1360599-76-3)
• EPA Substance Registry System: toluene-4-sulfonic acid 2-(4-chlorophenyl)-2-1H-[1,2,4]triazole-1-ylmethyl-[1,3]dioxolan-4-ylmethyl ester(1360599-76-3)

Safety Data

• Hazardous Substances Data: 1360599-76-3(Hazardous Substances Data)

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 51704-66-6 (+/-)-2,3-dihydroxypropyl tosylate 
• 58905-19-4 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone 
• 23737-51-1 solketal tosylate 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1430847-78-1 1-[2-(4-chlorophenyl)-4-(2-propoxyphenoxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-79-2 1-[[4-[(2-allyloxyphenoxy)methyl]-2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole 
• 1430847-80-5 1-[4-(2-butoxyphenoxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-81-6 1-[[4-[(2-(3-butenyloxy)phenoxy)methyl]-2-(4-chlorophenyl)-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole 
• 1430847-83-8 1-[2-(4-chlorophenyl)-4-(2-isobutoxyphenoxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-84-9 1-[4-(2-tert-butoxyphenoxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-85-0 1-{2-(4-chlorophenyl)-4-[2-(3-methyl-but-2-enyloxy)phenoxymethyl]-[1,3]-dioxolan-2-ylmethyl}-1H-[1,2,4]-triazole 
• 1430847-86-1 1-{2-(4-chlorophenyl)-4-[2-(3-methylbutoxy)phenoxymethyl]-[1,3]-dioxolan-2-ylmethyl}-1H-[1,2,4]-triazole 
• 1430847-87-2 1-[2-(4-chlorophenyl)-4-(2-cyclopentyloxyphenoxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-82-7 1-[4-(2-allylphenoxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-88-3 1-[4-(biphenyl-2-yloxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-89-4 1-[4-(2-benzylphenoxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-90-7 1-[4-(biphenyl-4-yloxymethyl)-2-(4-chlorophenyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 
• 1430847-91-8 1-[2-(4-chlorophenyl)-4-(naphthalen-1-yloxymethyl)-[1,3]-dioxolan-2-ylmethyl]-1H-[1,2,4]-triazole 

Relevant articles and documents

Synthesis and properties of brassinosteroid biosynthesis inhibitor fluorescent probe with dansyl moiety

Brassinosteroids (BRs) are important plant hormones that play key roles in plant development and defense responses to environmental cues. To explore the inhibition mechanism of BR biosynthesis, we report the synthesis of novel triazole derivatives with da

Synthesis and biological evaluation of novel azole derivatives as selective potent inhibitors of brassinosteroid biosynthesis

Brassinosteroids (BRs) are phytohormones that control several important agronomic traits, such as flowering, plant architecture, seed yield, and stress tolerance. To manipulate the BR levels in plant tissues using specific inhibitors of BR biosynthesis, a series of novel azole derivatives were synthesized and their inhibitory activity on BR biosynthesis was investigated. Structure-activity relationship studies revealed that 2RS, 4RS-1-[4-(2- allyloxyphenoxymethyl)-2-(4-chlorophenyl)-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4] triazole (G2) is a highly selective inhibitor of BR biosynthesis, with an IC50 value of approximately 46 ± 2 nM, which is the most potent BR biosynthesis inhibitor observed to date. Use of gibberellin (GA) biosynthesis mutants and BR signaling mutants to analyze the mechanism of action of this synthetic series indicated that the primary site of action is BR biosynthesis. Experiments feeding BR biosynthesis intermediates to chemically treated Arabidopsis seedlings suggested that the target sites of this synthetic series are CYP90s, which are responsible for the C-22 and/or C-23 hydroxylation of campesterol.