143096-86-0

Usage

Uses

Used in Pharmaceutical Industry:
2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride is used as a reagent in the pharmaceutical industry for the production of drugs and pharmaceutical intermediates. Its unique structure and properties make it a valuable building block for the synthesis of complex organic molecules, contributing to the development of novel therapeutic agents.
Used in Specialty Chemicals Production:
In the specialty chemicals sector, 2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride is utilized as an intermediate for the preparation of a variety of specialty chemicals. Its reactivity and structural features are harnessed to create compounds with specific applications in various industries.
Used in Agrochemicals Industry:
2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride is also an important intermediate in the agrochemicals industry, where it is used in the production of insecticides, fungicides, and herbicides. Its role in these applications is to provide the necessary functional groups for the active ingredients in these products, enhancing their efficacy and performance in agricultural settings.
Due to the potent reactivity of 2,2-Difluoro-1,3-benzodioxole-4-carbonyl chloride, it necessitates careful handling and storage to ensure safety and prevent accidents during its use in these various applications.

InChI:InChI=1/C8H4F2O4/c9-8(10)13-5-3-1-2-4(7(11)12)6(5)14-8/h1-3H,(H,11,12)/p-1

Upstream product

• 126120-85-2 2,2-difluoro-1,3-benzodioxole-4-carboxylic acid 

Downstream Products

• 161886-18-6 2,2-difluoro-1,3-benzodioxol-4-carbonitrile 
• 531508-46-0 (2,2-difluorobenzo[d][1,3]dioxol-4-yl)methanamine 

Relevant academic research and scientific papers

Benzodioxolene derivative with phosphonate and application of benzodioxolene derivative

The invention discloses an O,O-dimethyl-alpha-(2,2-difluoro-benzodioxol-4-formyl)(substituted phenyl)methylphosphonate derivative, wherein the derivative is represented by the general formula of a formula I, and in the formula I, R represents halogen, hyd

A homologous series of O- and N-functionalized 2,2-difluoro-1,3-benzodioxoles: An exercise in organometallic methodology

The conversion of 2,2-difluoro-1,3-benzodioxole, an exceptionally acidic arene, via a 4-lithiated intermediate into more than three dozen new derivatives was conceived as a case study. The lithiated species was trapped by C0-electrophiles (4-toluenesulfonyl azide, fluorodimethoxyborane, iodine), C1-electrophiles (carbon dioxide, N,N-dimethylformamide, formaldehyde, dimethyl sulfate), C2-electrophiles (oxalic acid diesters, oxirane), C3-electrophiles (oxetane), and higher alkyl iodides. The resulting carboxylic acid 1a may be treated with organolithium compounds to afford ketones (e.g. 10) and the aldehyde 9 can be condensed with nitromethane or acetic anhydride under basic conditions. If not oxidized with chromium trioxide to the corresponding carboxylic acids, the alcohols 2b, 2c, and 2d can be transformed into the corresponding bromides (12) or sulfonates (13). Their condensation with nitrogen-containing C0-nucleophiles (hydroxylamine, sodium azide, potassium phthalimide), C1-nucleophiles (potassium cyanide), and C2-nucleophiles (aceto-nitrile) opens a convenient access to the amines 3. Other reactions gave, despite a proven track record in other areas, only moderate yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

Herbicidal isoxazoles

The invention relates to isoxazole derivatives of formula (I): STR1 wherein: Ar represents phenyl optionally substituted by from one to three groups and wherein two substituents on adjacent positions of the phenyl ring, together with the two atoms to whic