143100-47-4

Upstream product

• 136057-11-9 dimethyl (2S,3aR,8aS)-8-benzenesulphonyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-1,2-dicarboxylate 
• 96-32-2 bromoacetic acid methyl ester 
• 98-09-9 benzenesulfonyl chloride 
• 79465-82-0 L-(2β,3aα,8aα)-1,2,3,3a,8,8a-hexahydro-1,2-dimethoxycarbonylpyrrolo<2,3-b>indole 

Downstream Products

• 143100-49-6 (R)-2-(1-Benzenesulfonyl-1H-indol-3-ylmethyl)-2-methoxycarbonylamino-succinic acid dimethyl ester 
• 143282-42-2 (R)-α-methylaspartic acid hydrochloride 

Relevant academic research and scientific papers

ENANTIOSPECIFIC SYNTHESIS OF AMINO ACIDS: PREPARATION OF (R)- AND (S)-α-METHYLASPARTIC ACID FROM (S)-TRYPTOPHAN

The enantiospecific synthesis of both antipodes of α-methylaspartic acid from (S)-tryptophan is described with the key steps being alkylation of the hexahydropyrroloindole 4, oxidative degradation of indoles and, for the preparation of the (R)-isomer, Barton reductive decarboxylation.