143123-64-2Relevant academic research and scientific papers
Synthesis of antimicrobial natural products targeting FtsZ: (+)-totarol and related totarane diterpenes
Kim, Michelle B.,Shaw, Jared T.
supporting information; experimental part, p. 3324 - 3327 (2010/11/02)
(Equation Presented). An efficient, convergent synthesis of totarol by a diastereoselective epoxide/alkene/arene bicyclization is described. The reported synthesis enables the preparation of related diterpenes totaradiol and totarolone as well as previously unavailable derivatives that exhibit comparable inhibition of the bacterial cell division protein FtsZ.
Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
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Page column 29, (2010/02/04)
This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor agonists, and which are represented by Formula I: wherein R1, R2, R3, R4, R5, A, and B are as defined in the specification, and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
