1431230-88-4Relevant articles and documents
Synthesis, spectroscopic characterization and structural investigation of a new symmetrically trisubstituted benzene derivative: 3,3′, 3′′-(Benzene-1,3,5-triyl)tripropiolic acid
Münch, Alexander S.,Katzsch, Felix,Weber, Edwin,Mertens, Florian O.R.L.
, p. 103 - 108 (2013)
The new 1,3,5-trisubstituted benzene derivative 1 featuring three propiolic acid side arms symmetrically attached to a benzene core has been synthesized. Spectroscopic studies including 1H and 13C NMR as well as FTIR measurements wer
Method for preparing propiolic acid and derivatives thereof under mild condition
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Paragraph 0161; 0162, (2018/09/08)
The invention provides a novel method for preparing propiolic acid compounds through a domino reaction. The method comprises a step of subjecting terminal alkyne compounds, hydrosilane and CO2 to thedomino reaction under the catalysis action of Lewis base so as to obtain propiolic acid compounds. According to the invention, common Lewis base is used as a promoter, and corresponding propiolic acidcompounds containing different function groups can be efficiently produced through a reaction of the terminal alkyne compounds with hydrosilane and normal-pressure CO2 under a mild condition (a temperature of 40 DEG D). According to the method, CO2 is used as a raw material; the cheap Lewis base is used as the promoter; usage of precious metals is avoided; the domino reaction is employed; purification and separation of intermediates are not needed; and reaction conditions are mild. Thus, the method is an efficient cheap green synthetic method and has good industrial application value.
