143129-49-1Relevant academic research and scientific papers
Iridium-catalyzed asymmetric hydrogenation of racemic β-keto lactams via dynamic kinetic resolution
Bao, Deng-Hui,Gu, Xue-Song,Xie, Jian-Hua,Zhou, Qi-Lin
supporting information, p. 118 - 121 (2017/11/27)
A highly efficient Ir-catalyzed asymmetric hydrogenation of racemic β-keto lactams via dynamic kinetic resolution (DKR) for the synthesis of optically active β-hydroxyl lactams has been described. With the Ir-SpiroSAP catalyst, a series of racemic β-keto lactams including β-keto γ-, δ-, and ?-lactams were hydrogenated to chiral β-hydroxy lactams in high yields (87-99%) with excellent enantio- and diastereoselectivity (83-99.9% ee, syn/anti: 97:3->99:1) at low catalyst loading under mild reaction conditions. This efficient method has been successfully applied in the synthesis of the chiral intermediate of fluoroquinolone antibiotic premafloxacine.
Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems
Hattori, Kouji,Yamada, Akira,Kuroda, Satoru,Chiba, Toshiyuki,Murata, Masayoshi,Sakane, Kazuo
, p. 383 - 386 (2007/10/03)
The synthesis, antibacterial activity and DHP-susceptibility of a series of novel carbapenems, directly linked with heterocyclic moiety are described. Especially, the compounds linked pyrrolidine-carbapenem exhibited to have a good antibacterial activity against Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa to maintain a good stability towards DHP-I.
A process for producing optically active pyrrolidine derivatives
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, (2008/06/13)
An optically active (3R,1'S)-3-[(1'-N-methylamino)ethyl]pyrrolidine is used as an intermediate for synthesis of pharmaceutical preparations such as anti-fungus agents. This product can be obtained in a new process having fewer steps, with higher purity an
