143142-90-9

Basic information

• Product Name: R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97
• Synonyms: R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97;(2R)-2-(Trifluoromethyl)oxirane (ee);(2R)-(+)-3,3,3-Trifluoro-1,2-propenoxide;(2R)-2-(Trifluoromethyl)oxirane, (2R)-1,2-Epoxy-3,3,3-trifluoropropane;(2R)-2-(trifluoromethyl)oxirane
• CAS NO: 143142-90-9
• Molecular Formula: C₃H₃F₃O
• Molecular Weight: 112.0505296
• Mol File: 143142-90-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 25-32 °C
• Flash Point: -15 °F
• Appearance: white crystal powder
• Density: 1.294 g/mL at 25 °C
• Vapor Pressure: 560mmHg at 25°C
• Refractive Index: n20/D <1.300
• Storage Temp.: 2-8°C
• CAS DataBase Reference: R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97(143142-90-9)
• EPA Substance Registry System: R-(+)-2-TRIFLUOROMETHYLOXIRANE, 97(143142-90-9)

Safety Data

• Hazard Codes: F+
• Statements: 12
• Safety Statements: 3
• RIDADR: UN 1993 3/PG 1
• WGK Germany: 3
• Hazardous Substances Data: 143142-90-9(Hazardous Substances Data)

Usage

Uses

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize: Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein. (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.

InChI:InChI=1/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1

Upstream product

• 359-41-1 1,1,1-trifluoro-2,3-epoxypropane 
• 431-35-6 3-bromo-1,1,1-trifluoroacetone 
• 137429-44-8 3-bromo-1,1,1-trifluoropropan-2-ol 

Downstream Products

• 374-01-6 (R)-1,1,1-trifluoropropanol 
• 1204344-00-2 (2R)-1,1,1-trifluoro-3-[(4-methoxybenzyl)oxy]propan-2-ol 
• 147730-41-4 (2S)-1,1,1-trifluoro-3-phenylsulfanyl-propan-2-ol 

Relevant articles and documents

COMPOUNDS AND THEIR METHODS OF USE

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Method for Industrial Production of Optically Active Fluoroalkyl Ethylene Oxide

It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl chloromethyl ketone with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity. Then, it is possible to obtain a fluoroalkyl ethylene oxide by treating the alcohol with a base. Industrial implementation of the production method of the present invention is easy.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.