147730-41-4

Upstream product

• 34509-09-6 1,1,1-trifluoro-3-(phenylthio)propan-2-one 
• 100-68-5 methyl-phenyl-thioether 
• 110929-41-4 2-acetoxy-1,1,1-trifluoro-3-(phenylthio)propane 
• 130025-34-2 (S)-2-trifluoromethyl-oxirane 
• 882-33-7 diphenyldisulfane 
• 108-98-5 thiophenol 
• 143142-90-9 (2R)-2-(trifluoromethyl)oxirane 
• 88790-04-9 2-hydroxy-3,3,3-trifluoropropyl phenyl sulfide 
• 182230-66-6 Propionic acid 2,2,2-trifluoro-1-phenylsulfanylmethyl-ethyl ester 
• 359-41-1 1,1,1-trifluoro-2,3-epoxypropane 

Downstream Products

• 110929-41-4 2-acetoxy-1,1,1-trifluoro-3-(phenylthio)propane 
• 88790-05-0 Methanesulfonic acid 2,2,2-trifluoro-1-phenylsulfanylmethyl-ethyl ester 

Relevant academic research and scientific papers

PYRAZOLYLAMINOBENZIMIDAZOLE DERIVATIVES AS JAK INHIBITORS

The present invention provides compounds of the formula below (I'): where R, and R1-R3 are as described herein, methods of treating patients for certain types of autoimmune diseases and cancer, and processes for preparing the compounds.

JAK1 inhibitors

The present invention relates to certain benzimidazole compounds, or pharmaceutically acceptable salts thereof, that inhibit Janus kinase 1 (JAK1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat certain types of cancer.

Anodic methoxylation of 2-acyloxy-3,3,3-trifluoropropyl sulfides accompanying with [1,2]-rearrangement of the acyloxy group and anodic cyclization of 2-(t-butoxycarbonyl)oxy-3,3,3-trifluoropropyl sulfide

Anodic methoxylation of 2-acyloxy-3,3,3-trifluoropropyl sulfides was carried out in methanol containing Et3N-3HF as a supporting electrolyte and mediator using an undivided cell to provide the corresponding α-methoxylated products and unexpecte

A preparation of trifluorolactic aldehyde

A five-step preparation of 2-benzoyloxy-333-trifluoropropanal from 1,2- epoxy-3,3,3-trifluoropropane via Pummerer rearrangement is described. The total yield of the aldehyde from the epoxide was 90%. The aldehyde kept its optical purity when it was in hydrate form, but it was found to readily racemize in its formyl form. The utilization of selenium instead of sulfur in these procedures offered advantages in controlled oxidation of the heteroatom for Pummerer rearrangement and the subsequent hydrolysis of Pummerer product, an aldehyde equivalent.

Asymmetric reduction of trifluoromethyl ketones containing a sulfur functionality by the alcohol dehydrogenase from Geotrichum

The reduction of trifluoromethyl ketones containing a sulfur functionality by the crude alcohol dehydrogenase from Geotrichum proceeded successfully, and the corresponding optically active alcohols were synthesized with high yields and excellent enantiose

Preparation of Sulfur-Containing Optically Active Secondary Alcohols Based on Pichia farinosa-Catalyzed anti-Prelog-Rule Reduction as the Key Step

A Pichia farinosa IAM 4682 mediated reduction of sulfur containing ketones afforded secondary alcohols with (R)-absolute configuration. For example, 4-(phenylthio)-2-butanone and 4-(phenylsulfonyl)-2-butanone afforded (R)-4-(phenylthio)-2-butanol (91%ee) in 90% yield and (R)-4-(phenylsulfonyl)-2-butanol (97%ee) in 94% yield, respectively. In the case that the ee of the product was not satisfactory, any contaminating (S)-enantiomer was selectively oxidized by Rhodococcus rhodochrous IFO 15564 to leave pure (R)-enantiomer. The substrate specificity of Pichia farinosa-mediated reduction and Rhodococcus rhodochrous-mediated oxidation was further examined.

Catalytic asymmetric synthesis of new halogenated chiral synthons

Two-step and practical asymmetric syntheses of enantiomerically pure 4-trifluoromethyl-2.2-dioxo-1,3,2-dioxathiolane and 4-trichloromethyl-2,2-dioxo-1,3,2-dioxathiolane (>98% ee) have been achieved. Catalytic asymmetric dihydroxylation (AD) of 3,3,3-trifl

Highly stereocontrolled access to 1,1,1-trifluoro-2,3-epoxypropane via lipase-mediated kinetic resolution of 1,1,1-trifluoro-3-(phenylthio)propan-2-ol and its application

1,1,1-Trifluoro-3-(phenylthio)propan-2-ol was prepared in high enantiomeric purity by lipase-mediated kinetic resolution of the corresponding esters. The resolved alcohol was successfully converted into 1,1,1 -trifluoro-2,3-epoxypropane and/or used in the

Oxidation of Fluoroalkyl-Substituted Carbinols by the Dess-Martin Reagent

The efficient oxidation of mono-, di-, tri-, and perfluoroalkyl-substituted carbinols has been accommplished by the Dess-Martin periodinane oxidant.A variety of functional groups are compatible with the oxidation procedure.Monitoring the oxidation by 19F NMR indicated that a discreet periodinane intermediate is formed during the course of the reaction.Nonnucleophilic or sterically encumbered α-thiofluoro carbinols were readily oxidized; however, a nucleophilic α-thio-substituted trifluoromethyl carbinol was not.A tert-butyl alcohol modified periodinane oxidant was ultimately employed to achieve oxidation in this example.

2-HALOVINYL ARYL SULFONES: NEW COUPLING REAGENTS FOR CARBOXAMIDE FORMATION

E-2-Chlorovinyl p-nitrophenyl sulfone 6 and 2-bromo-2-trifluoromethylvinyl phenyl sulfone 7a reacted with carboxylic acids in the presence of a molar equiv of Et3N affording the corresponding 2-acyloxyvinyl sulfones 8, 11, 17, 18, 22, 25, 28 and 29.The latter, on treatment with amines, gave amides 9, 13, 19, 23 and 26 and peptides 30 and 32.These reagents 6 and 7a were also used for the formation of N-methylanilides 13d, 13e, 19d, 23 and 26.Particularly, 6 was successfully used for synthesis of a macrocyclic lactam 23 involving a N-methylanilide moiety.The amidation reac tions proceeded under essentially neutral conditions.Therefore, base-sensitive β-hydroxycarboxy-N-methylanilides such as 26, whose structural unit was involved in maytansine 5, could be prepared by the present method.The reagent 6 was also effective for the preparation of peptides such as Val-N-MeVal derivatives (e.g.32), which were difficult to prepare by other methods.