143143-11-7

Basic information

• Product Name: 2,2,2-Trifluoro-N-[(1R,2R)-1-methyl-2-((R)-1-methyl-but-3-enyloxy)-2-phenyl-ethyl]-acetamide
• Synonyms: 2,2,2-Trifluoro-N-[(1R,2R)-1-methyl-2-((R)-1-methyl-but-3-enyloxy)-2-phenyl-ethyl]-acetamide
• CAS NO: 143143-11-7
• Molecular Weight: 315.336
• Mol File: 143143-11-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2,2-Trifluoro-N-[(1R,2R)-1-methyl-2-((R)-1-methyl-but-3-enyloxy)-2-phenyl-ethyl]-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-[(1R,2R)-1-methyl-2-((R)-1-methyl-but-3-enyloxy)-2-phenyl-ethyl]-acetamide(143143-11-7)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-[(1R,2R)-1-methyl-2-((R)-1-methyl-but-3-enyloxy)-2-phenyl-ethyl]-acetamide(143143-11-7)

Safety Data

• Hazardous Substances Data: 143143-11-7(Hazardous Substances Data)

Upstream product

• 75-07-0 acetaldehyde 
• 143143-10-6 (R,R)-2-trifluoroacetylamino-1-trimethylsilyloxy-1-phenylpropane 
• 762-72-1 allyl-trimethyl-silane 
• 205869-11-0 2,2,2-Trifluoro-N-((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-acetamide 
• 53643-20-2 (1R,2R)-norephedrine hydrochloride 

Downstream Products

• 64584-92-5 (R)-pent-4-en-2-ol 
• 57573-45-2 2,2,2-trifluoro-N-[(1R)-1-methyl-2-phenylethyl]acetamide 
• 139079-91-7 (4R)-1-penten-4-yl-(αR)-α-methoxy-α-trifluoromethylphenylacetate 

Relevant articles and documents

Enantioselective synthesis of tertiary homoallylic alcohols via diastereoselective addition of allylsilanes to ketones

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Synthesis of Enantiopure Homoallylic Alcohols and Ethers by Diastereoselective Allylation of Aldehydes

Enantiopure homoallylic alcohols 5, which are important building blocks in organic synthesis, are obtained with an ee of greater than 99percent and a yield of 75-95percent by cleavage of the secondary homoallylic ethers 4 using sodium in liquid ammonia.The ethers 4 are formed with excellent diastereoselectivity and in 52-89percent yield by treatment of the aldehydes 1 with the trimethylsilyl ether of N-trifluoroacetylnorpseudoephedrine (2) in the presence of a catalytic amount of TMS triflate or TMS borontriflate, followed by addition of allylsilane 3.Nearly all achiral aliphatic aldehydes employed gave a diastereoselectivity of over 99:1.With the chiral aldehydes 24, the difference between matched and mismatched pairs was low; this reveals that there is strong reagent control.- Keywords: allylations; allylsilanes; double stereodifferentiation; ephedrine; homoallylic alcohols