1431473-20-9

Basic information

• Product Name: 2-(2H-tetrazol-2-yl)benzoic acid
• Synonyms: 2-(2H-tetrazol-2-yl)benzoic acid
• CAS NO: 1431473-20-9
• Molecular Weight: 190.161
• Mol File: 1431473-20-9.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: 2-(2H-tetrazol-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2H-tetrazol-2-yl)benzoic acid(1431473-20-9)
• EPA Substance Registry System: 2-(2H-tetrazol-2-yl)benzoic acid(1431473-20-9)

Safety Data

• Hazardous Substances Data: 1431473-20-9(Hazardous Substances Data)

Upstream product

• 288-94-8 1H-tetrazole 
• 88-67-5 2-Iodobenzoic acid 
• 108-18-9 diisopropylamine 
• 89797-68-2 5-(ethylthio)-1H-tetrazole 
• 288-94-8 2H-tetrazole 

Downstream Products

• 1604795-11-0 methyl 4-cyano-2-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3,4-tetrazol-2-yl)phenyl]carbonyl}piperidin-3-yl]oxy}pyridine-3-carboxylate 
• 1612786-16-9 2-(((3R,6R)-1-(2-(2H-tetrazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile 

Relevant articles and documents

Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole

2-(2H-Tetrazol-2-yl)benzoic acid 1 and analogs were prepared via Cu(I) catalyzed C-N coupling of 2-iodo or 2-bromo benzoic acids with 5-(ethylthio)-1H- tetrazole followed by reductive cleavage of the thioether bond. The C-N coupling was regioselective toward the N2-position on tetrazole. The scope of this methodology was demonstrated on a series of 2-halobenzoic acid substrates in moderate yields.

6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

HETEROARYL OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.