1431526-79-2Relevant academic research and scientific papers
Highly diastereo- and enantioselective organocatalytic domino michael/aldol reaction of acyclic 3-halogeno-1,2-diones to α,β-unsaturated aldehydes
Lefranc, Alice,Guenee, Laure,Alexakis, Alexandre
supporting information, p. 2172 - 2175 (2013/06/05)
The first organocatalytic diastereo- and enantioselective domino Michael/aldol reaction of 3-halogeno-1,2-diones to α,β-unsaturated aldehydes has been achieved. This transformation tolerates a large variety of electronically different substituents on both reactive partners and allows the synthesis of challenging cyclopentanone derivatives with four contiguous stereogenic centers in excellent diastereoselectivities (>20:1 dr) as well as good yields (69-97%), and enantioselectivities (up to 94% ee).
