29425-81-8

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 532-27-4 1-chloroacetophenone 
• 100-42-5 styrene 
• 2403-27-2 1-(4-bromophenyl)-3-phenyl-2-propen-1-one 
• 99-90-1 para-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 72758-69-1 (E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one 

Downstream Products

• 76283-67-5 1-(4-Bromo-phenyl)-2-hydroxy-3-phenyl-3-thiocyanato-propan-1-one 
• 100954-46-9 3-oxo-2-phenyl-3-(4-bromophenyl)propanal 
• 27047-19-4 1-(4-bromophenyl)-2-phenylsulfanylethanone 
• 438631-73-3 trans-(2R,3S)-epoxy-3-phenyl-1-(4-bromophenyl)-propan-1-one 
• 67295-27-6 1-(4-bromo-phenyl)-2-hydroxy-3-morpholin-4-yl-3-phenyl-propan-1-one 
• 39229-12-4 4-bromobenzil 
• 63987-90-6 1-(4-bromophenyl)-2,2-dimethoxyethanone 
• 2001-29-8 1-(4-bromophenyl)-2-phenyl-ethan-1-one 
• 1431527-11-5 C₁₅H₁₂BrClO₂ 
• 1431526-97-4 C₂₄H₁₈BrClO₃ 
• 1431526-79-2 3-chloro-1-(p-bromophenyl)-3-phenylpropane-1,2-dione 

Relevant academic research and scientific papers

Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction

The invention relates to application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric epoxidation reaction of chalcone compounds. According to the application, alpha, beta-unsaturated ketone shown in a formula (1) and tert-butyl hydroperoxide react in the presence of organic alkali under the combined catalytic action of a chiral TADDOL ligand shown in a formula (3) and rare earth metal amide in an anhydrous, oxygen-free and protective atmosphere to obtain the chiral epoxy compound shown in the formula (2) after the reaction is completed, wherein R1 is selected from hydrogen, alkyl, halogen, alkoxy, trifluoromethyl, nitro or cyano, R2 is selected from phenyl, substituted phenyl, naphthyl, furyl or thienyl; R3 and R4 are respectively and independently selected from alkyl, phenyl or R3 and R4 and carbon atoms connected with R3 and R4 form naphthenic base; Ar is phenyl, substituted phenyl, biphenyl or naphthyl; the molecular formula of the rare earth metal amide is RE [N (SiMe3) 2] 3. The method has the advantages of wide substrate application range, high yield and high enantioselectivity.

Design and synthesis of bi-functional Co-containing zeolite ETS-10 catalyst with high activity in the oxidative coupling of alkenes with aldehydes for preparing α,β-epoxy ketones

Developing highly efficient heterogeneous catalysts for organic synthesis is of great importance in modern synthetic chemistry. In this work, Co (or Ni)-containing mesoporous zeolite ETS-10 (Co-METS-10 and Ni-METS-10) with both metal and strong basic site

Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands

A range of chiral quinazolinol ligands were efficiently synthesized and subsequently investigated for catalytic chiral induction in both the asymmetric phenylation of aryl aldehydes and the asymmetric epoxidation of chalcones. Encouragingly, high enantioselectivities (up to 95%) and yields (up to 98%) were achieved under the optimized reaction conditions.

A transition-metal-free, one-pot procedure for the synthesis of α,β-epoxy ketones by oxidative coupling of alkenes and aldehydes via base catalysis

A new strategy for the synthesis of epoxides is presented. This process allows the direct synthesis of epoxides from alkenes and aldehydes through C-H functionalization and C-C/C-O bond formation. This journal is

Preparation of mesoporous zeolite ETS-10 catalysts for high-yield synthesis of α,β-epoxy ketones

Developing highly active heterogeneous catalysts for the efficient construction of valuable building blocks is of great importance to synthetic chemistry. For this purpose, a mesoporous zeolite ETS-10 (METS-10) is synthesized by using a mesoscale silane surfactant as a template and applied to achieve highly efficient syntheses of α,β-epoxy ketones by employing simple alkenes and aldehydes as starting materials. The high activity of the METS-10 catalyst is attributed to its unique porous structure and basicity. Electron paramagnetic resonance characterization results and theoretical calculation experimental data reveal that the strong basic sites on METS-10 catalyst can activate the reaction substrate and intermediate. In addition, the mesopores in METS-10 catalyst benefit the mass transfer and further improve the catalytic activity. Mesoporous zeolite ETS-10 is synthesized by using mesoscale silane surfactant as a template and applied to the highly efficient synthesis of α,β-epoxy ketones by employing simple alkenes and aldehydes as starting materials. The high activity of the mesoporous ETS-10 catalyst is attributed to its unique porous structure and basicity.

Biomimetic hydrogenation: A reusable NADH co-enzyme model for hydrogenation of α,β-epoxy ketones and 1,2-diketones

A biomimetic method has been developed to transform α,β-epoxy ketones or 1,2-diketones into corresponding β-hydroxy ketones or α-hydroxy ketones using a catalytic amount of BNAH or BNA +Br-. The regeneration of BNAH or BNA+Br - is achieved by a mixture of HCOOH/Et3N. A radical mechanism is proposed to explain these observations.

PAA-supported Hantzsch 1,4-dihydropyridine ester: An efficient catalyst for the hydrogenation of α,β-epoxy ketones

A new type of water-soluble polymer-supported NADH co-enzyme model-PAA (polyacrylic acid)-supported Hantzsch 1,4-dihydropyridine ester (PAA-HEH) was designed and synthesized. Catalytic amount of the supported reagent was used in the hydrogenation of α,β-epoxy ketones to the corresponding β-hydroxy ketones and showed great catalytic efficiency in the reduction reaction. This PAA-HEH was an optimal potential for recycling use.

The Kinetics of the Darzens Reaction of p-Substituted Benzaldehydes and Phenacyl Chloride

The rate constants for the base-catalyzed Darzens reactionof p-substituted benzaldehydes and phenacyl chloride have been measured at two temperatures in aqueous dioxane.Enthalpies and entropies of activation have been evaluated.The reactivity of the p-substituted benzaldehydes was found to follow the order p-NO2> p-Cl> p-Br> H> p-CH3> p-OCH3.The kinetic data can be correlated with ρ values according to the Hammett equation.

NEW EPOXIDATION OF OLEFINS WITH SUPEROXIDE ANION IN THE PRESENCE OF ORGANIC SULFUR COMPOUNDS

Epoxidation of olefins such as stilbene and chalcone with superoxide anion in the presence of several sulfur compounds was investigated.