1431556-38-5

Basic information

• Product Name: C₁₆H₂₃NO₇S
• Synonyms: C₁₆H₂₃NO₇S
• CAS NO: 1431556-38-5
• Molecular Weight: 373.427
• Mol File: 1431556-38-5.mol

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₃NO₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₃NO₇S(1431556-38-5)
• EPA Substance Registry System: C₁₆H₂₃NO₇S(1431556-38-5)

Safety Data

• Hazardous Substances Data: 1431556-38-5(Hazardous Substances Data)

Upstream product

• 76757-90-9 N-(tert-butoxycarbonyl)-D-tyrosine methyl ester 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 149818-98-4 methyl (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanoate 
• 1431556-74-9 C₂₂H₂₅Cl₂NO₅ 
• 1431556-39-6 methyl (R)-2-((tert-butoxycarbonyl)amino)-3-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)propanoate 

Relevant articles and documents

Synthesis method of LCZ696 midbody

The invention discloses a synthesis method of an LCZ696 midbody (R)-tertiary butyl (1-([1,1'-biphenyl]-4-base)-3-hydroxyl propane-2-base) carbamic acid ester. The preparation method comprises the following steps that (1) a raw material BOC-D-tyrosine I reacts with substituent sulfonyl chloride to obtain a midbody II; (2) the midbody II and a phenyl Grignard reagent are subjected to coupling to obtain a midbody III; and (3) the midbody III is reduced through potassium borohydride to obtain (R)-tertiary butyl (1-([1,1'-biphenyl]-4-base)-3-hydroxyl propane-2-base) carbamic acid ester IV. The synthesis method utilizes cheap n-tosyl-l-alanyloxyindole to replace expensive and virulent trifluoromethanesulfonic acid, and meanwhile avoids to use the expensive metal catalyst Pd, the experiment is easy to operate, the yield is high, and the LCZ696 midbody is suitable for large-scale production.