143157-25-9

Basic information

• Product Name: 2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate
• Synonyms: 2-Deoxy-2,2-difluoro-3,5-bisbenzolyloxy-D-riboflouranose;2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate
• CAS NO: 143157-25-9
• Molecular Formula: C19H16F2O6
• Molecular Weight: 378.3235464
• Mol File: 143157-25-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 495.925 °C at 760 mmHg
• Flash Point: 253.726 °C
• Appearance: /
• Density: 1.412 g/cm³
• PKA: 9.95±0.70(Predicted)
• CAS DataBase Reference: 2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate(143157-25-9)
• EPA Substance Registry System: 2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate(143157-25-9)

Safety Data

• Hazardous Substances Data: 143157-25-9(Hazardous Substances Data)

Usage

General Description

2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate is a chemical compound that is part of the ribose family. It is a derivative of 2-deoxy-2,2-difluoro-D-ribose that has been modified with benzoate groups at the 3 and 5 positions. 2-Deoxy-2,2-difluoro-D-ribose-3,5-dibenzoate is often used in organic synthesis and medicinal chemistry as a building block for creating new molecules with potential pharmaceutical applications. Its unique structure and properties make it a valuable tool for researchers working in the fields of drug discovery and chemical biology.

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Relevant articles and documents

High-selectivity synthesis method for gemcitabine intermediate

The invention discloses a high-selectivity synthesis method for a gemcitabine intermediate. The high-selectivity synthesis method specifically comprises the following process: Step 1, synthesis of T1;Step2, synthesis of T2, to be specific, 550kg of hydrogen peroxide is dropwise added into the T1, and a reaction is controlled to produce the T2; Step3, synthesis of T3, to be specific, sodium acetate trihydrate or sodium carbonate is added into a reaction kettle, the PH value is adjusted with glacial acetic acid, a 10%-15% sodium hypochlorite aqueous solution is dropwise added, and a reaction iscontrolled to produce the T3; Step 4, synthesis of T4; Step 5, synthesis of T5; Step 6, synthesis of T6; Step 7, synthesis of T7; Step 8, synthesis of T8; and Step9, T8 configuration transformation.The high-selectivity synthetic method for the gemcitabine intermediate can reduce the production cost, and meanwhile, can also increase the yield of the gemcitabine intermediate.

Method for recovering mother liquor of gemcitabine intermediate

The invention provides a method for recovering mother liquor of a gemcitabine intermediate, and relates to the technical field of purification. The method for recovering the mother liquor of the gemcitabine intermediate provided by the invention comprises the following steps of: performing acidolysis of crystallization mother liquor containing a compound 5 and a compound 10 so as to obtain a mixture of a compound 3 and a compound 9; mixing the mixture of the compound 3 and the compound 9 with aniline, and performing dehydration reaction to obtain a mixture of Schiff base 12 and the compound 9; performing separation of the mixture of the Schiff base 12 and the compound 9 to obtain high-purity Schiff base 12; performing hydrolysis of the high-purity Schiff base 12 to obtain the compound 3; and mixing the compound 3 with methylsulfonyl chloride, and performing acylation reaction so as to obtain the high-purity compound 5. The method provided by the invention can remove the compound 10 in the crystallization mother liquor to obtain the high-purity compound 5, so that the yield and the purity of hydrochloride, namely gemcitabine hydrochloride, are improved.

Preparation method of cytidine

The invention provides a preparation method of cytidine 1, which comprises the following steps: (1) carrying out a condensation reaction on a compound 6 and a compound 7 in the presence of stannic chloride to generate a compound 8; (2) removing an alpha-isomer and other reaction impurities in the compound 8 to obtain the beta-isomer compound 8; and (3) carrying out a deprotection reaction on the beta-isomer compound 8 in the presence of an alcohol solvent, and then carrying out a salt forming reaction with hydrochloric acid to obtain a compound 1. The nucleoside compound 8 can be obtained withhigh beta-stereoselectivity starting from a cheap raw material 7 with a mixed anomeric carbon configuration, especially the raw material 7a, and a slightly excessive basic group 6, especially the basic group 6a; the trace alpha-compound 8 isomer impurities can be removed from the nucleoside compound 8 through a simple pulping method; and subsequently, deprotection and salifying reactions for beta-compound 8 have high yield, so that the method can reduce the production cost of the compound 1.