143159-49-3Relevant academic research and scientific papers
Synthesis and antimicrobial activities of metal(II) complexes with 2,4-diiodo-6-phenyliminomethyl-phenol
Xu, Suo-Ping,Zhu, Hai-Liang
, p. 3291 - 3300 (2010)
A bidentate ligand, 2,4-diiodo-6-phenyliminomethyl-phenol (HL) has been synthesized from 3,5-diiodosalicylaldehyde and phenylamine in ethanol. Five mononuclear complexes have been synthesized from 2,4-diiodo-6-phenyliminomethyl- phenol reaction with CuCl2 2H2O, NiCl2 6H 2O, CoCl2 6H2O, MnCl2 4H2O, and ZnCl2 in ethanol or tetrahydrofuran (THF). The complexes were characterized by UV, infrared, ESI-MS, and elemental analyses. Complexes bis(2,4-diiodo-6-phenyliminomethyl-phenol)-copper(II) (1) and bis(2,4-diiodo-6-phenyliminomethyl-phenol)-zinc(II)-THF (5) were characterized by X-ray crystallography. Based on the crystal structure analysis of 1 and 5, coupled to their spectral similarity with other complexes prepared (2, 3, 4), we conclude that 2, 3, and 4 have similar structures to 1. The metal(II) in each complex is four-coordinate by two nitrogens and two oxygens from two ligands. All the complexes were assayed for antibacterial (Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae) activities by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Among the complexes tested, 1 showed the most favorable antimicrobial activity with minimum inhibitory concentrations of 3.125, 6.25, 6.25, 3.125, 3.125, 6.25 g mL-1 against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. coli, and E. cloacae, respectively.
Design, synthesis, and pharmacological investigation of iodined salicylimines, new prototypes of antimicrobial drug candidates
Xu, Suo-Ping,Lv, Peng-Cheng,Shi, Lei,Zhu, Hai-Liang
experimental part, p. 282 - 290 (2011/07/08)
A series of 3,5-diiodo-salicylalidene Schiff bases (compounds 1 - 35) has been synthesized and tested for antimicrobial activity. The compounds were assayed for antibacterial activities by the MTT method. Some of the compounds inhibit the growth of a broad range of bacteria including the species of Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Enterobacter cloacae. Among them, compounds 2-[(4-chloro-phenylimino)-methyl]-4,6-diiodo-phenol 11 and 2,4-diiodo-6-[(2- morpholin-4-yl-ethylimino)methyl]phenol 19 showed the most potent antibacterial activity with MIC of 3.1, 12.9, 3.3, 6.5, 12.9, 3.3 and 3.2, 12.8, 3.2, 12.8, 12.8, 3.2 μM against B. subtilis, S. aureus, S. faecalis, P. aeruginosa, E. Coli, and E. cloacae, respectively.
