1431616-09-9

Basic information

• Product Name: ethyl 2-phenyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate
• CAS NO: 1431616-09-9
• Molecular Weight: 378.394
• Mol File: 1431616-09-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-phenyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-phenyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(1431616-09-9)
• EPA Substance Registry System: ethyl 2-phenyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(1431616-09-9)

Safety Data

• Hazardous Substances Data: 1431616-09-9(Hazardous Substances Data)

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 
• 4406-77-3 2-Phenyl-1,3,2-dioxaborinane 
• 801306-50-3 ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate 

Relevant articles and documents

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C-H activation

A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C-H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selective transformation can be performed with different amines and arylboronate esters. Additionally, the directing group can be cleaved, taking advantage of an unprecedented detrifluoromethylation reaction.