801306-50-3

Basic information

• Product Name: Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate
• Synonyms: Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate;1-[3-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid ethyl ester
• CAS NO: 801306-50-3
• Molecular Formula: C14H17F3N2O2
• Molecular Weight: 302.2921896
• Mol File: 801306-50-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(801306-50-3)
• EPA Substance Registry System: Ethyl 1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate(801306-50-3)

Safety Data

• Hazardous Substances Data: 801306-50-3(Hazardous Substances Data)

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 65753-47-1 2-chloro-3-trifluoromethyl-pyridine 

Downstream Products

• 1431616-09-9 ethyl 2-phenyl-1-[3-(trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylate 
• 821768-09-6 3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid 

Relevant articles and documents

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C-H activation

A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C-H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to avoid bis-arylation. This highly selective transformation can be performed with different amines and arylboronate esters. Additionally, the directing group can be cleaved, taking advantage of an unprecedented detrifluoromethylation reaction.