1431772-23-4

Basic information

• Product Name: 5-(2,5-dimethylphenyl)-2-p-tolyl-2H-1,2,3-triazole N-oxide
• Synonyms: 5-(2,5-dimethylphenyl)-2-p-tolyl-2H-1,2,3-triazole N-oxide
• CAS NO: 1431772-23-4
• Molecular Weight: 279.341
• Mol File: 1431772-23-4.mol

Chemical Properties

• CAS DataBase Reference: 5-(2,5-dimethylphenyl)-2-p-tolyl-2H-1,2,3-triazole N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-dimethylphenyl)-2-p-tolyl-2H-1,2,3-triazole N-oxide(1431772-23-4)
• EPA Substance Registry System: 5-(2,5-dimethylphenyl)-2-p-tolyl-2H-1,2,3-triazole N-oxide(1431772-23-4)

Safety Data

• Hazardous Substances Data: 1431772-23-4(Hazardous Substances Data)

Upstream product

• 1431772-07-4 2-(4-methylphenyl)-1,2,3-triazole N-oxide 
• 85199-06-0 2,5-dimethylphenyl boronic acid 
• 553-94-6 4-bromo-m-xylene 
• 75815-82-6 2-(2-(p-tolyl)hydrazono)acetaldehyde 
• 539-44-6 N-4-methylphenylhydrazine 
• 106-42-3 para-xylene 

Relevant articles and documents

Room-temperature oxidative Suzuki coupling reaction of 1,2,3-triazole N-oxides

This study develops a new efficient pathway for synthesis of 2,4-disubstituted 1,2,3-triazoles through regioselective direct arylation between 2-aryl-1,2,3-triazole N-oxides and Ar-B(OH)2. The reaction proceeds smoothly at room temperature and exhibits good yield and high C5 position selectivity. The possible pathway of oxidative Suzuki coupling is also discussed. This simple methodology can be used to construct 2,4-disubstituted 1,2,3-triazole moiety.

Site-selective direct arylation of 1,2,3-triazole N-oxides

An efficient route for the synthesis of 2,4-disubstituted 1,2,3-triazoles by the regioselective direct arylation of 2-aryl-1,2,3-triazole N-oxides with Ar-X [X = Br, I and B(OH)2] is demonstrated. The reaction proceeds through Pd-catalyzed C-H bond activation, and the influence of the aryl halides on the reactivity is investigated. An efficient route for the synthesis of 2,4-disubstituted 1,2,3-triazoles by the regioselective direct arylation of 2-aryl-1,2,3-triazole N-oxides with Ar-X [X = Br, I and B(OH)2] is demonstrated. The reaction proceeds through Pd-catalyzed C-H bond activation, and the influence of the aryl halides on the reactivity is investigated. Copyright

Palladium-catalyzed olefination and arylation of 2-substituted 1,2,3-triazole N -oxides

Two highly efficient protocols for the regioselective synthesis of 2-substituted 4-alkenyl- and 4-aryl-1,2,3-triazoles by the palladium-catalyzed C-H functionalization of 1,2,3-triazole N-oxides are reported. A possible pathway of direct alkenylation with 1-octene and vinyl acetate is discussed.