1431978-07-2

Upstream product

• 227617-24-5 2-(4-methoxy-benzyl)-2H-pyrazol-3-yl-amine monohydrochloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 3528-45-8 1-(4-methoxybenzyl)-1H-pyrazol-5-amine 

Downstream Products

• 1431978-09-4 6-(4-hydroxy-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 1431978-10-7 {(R)-1-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carbonyl]-pyrrolidin-3-yl} carbamic acid tert-butyl ester 
• 1246553-04-7 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 1431977-12-6 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2,2,6,6-tetramethyl-piperidin-4-yl)-amide trrifluoroacetate salt 
• 1431978-16-3 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid(1-Boc-piperidin-4-yl)-amide 
• 1431977-13-7 6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid piperidin-4-ylamide hydrochloride salt 
• 1431977-27-3 ((R)-3-amino-pyrrolidin-1-yl)-[6-(4-hydroxy-phenyl)-1H-pyrazolo[3,4-b]-pyridin-4-yl]-methanone hydrochloride salt 
• 1431978-08-3 1-(4-methoxy-benzyl)-6-trifluoromethanesulfonyloxy-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to 1 H-pyrazolo[3,4-b]pyridine compounds of the formula (I) in which R1, R2, R3 and R4 are defined as indicated below. The compounds of the formula I are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

6-(4-Hydroxy-phenyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors

The present invention relates to 1H-pyrazolo[3,4-b]pyridine compounds of the formula I, in which R1, R2, R3 and R4 are defined as indicated below. The compounds of the formula I are kinase inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula I, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.