1431986-46-7

Upstream product

• 24706-47-6 3-(4-chlorophenylamino)-5,5-dimethylcyclohex-2-enone 
• 70780-36-8 2-hydroxy-2-(2-oxo-2-phenylethyl)-1H-indene-1,3(2H)-dione 

Relevant academic research and scientific papers

Regiospecific synthesis of 1,5,6,7-tetrahydro-4H-indol-4-ones via dehydroxylated [3+2] cyclization of β-hydroxy ketones with cyclic enaminones

A new p-TsOH-promoted dehydroxylated [3+2] cyclization strategy has been established, allowing a flexible, practical and regiospecific approach to 23 examples of 1,5,6,7-tetrahydro-4H-indol-4-ones from low-cost and readily accessible β-hydroxy ketones and cyclic enaminones. Notably features of this work include broad functional group compatibility, mild reaction conditions and good reaction yields.