1432062-35-5Relevant academic research and scientific papers
Chemodivergent, multicomponent domino reactions in aqueous media: L-proline-catalyzed assembly of densely functionalized 4H-pyrano[2,3-c]pyrazoles and bispyrazolyl propanoates from simple, acyclic starting materials
Prasanna, Pitchaimani,Perumal, Subbu,Menendez, J. Carlos
, p. 1292 - 1299 (2013)
A library of 4H-pyrano[2,3-c]pyrazol-6-amines was synthesized in excellent yield employing an l-proline-catalyzed, on-water four-component domino reaction from hydrazines, β-dicarbonyl compounds, nitriles and dialkyl acetylenedicarboxylates that generates two rings by the creation of C-C (two), C-N, CN and C-O bonds and presumably involves a sequence of hydrazone formation, cyclocondensation, Michael, [1,3]-hydrogen shift, Michael addition and 6-exo-dig annulation steps. When alkyl propiolates were employed, a three-component reaction took place furnishing alkyl 3,3-bis(5-hydroxy-1H- pyrazol-4-yl)propanoates via a double Michael domino process.
