613-85-4

Usage

Uses

Used in Pharmaceutical Research and Synthesis:
(2,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as a key intermediate in the synthesis of various organic compounds and pharmaceutical products. Its ability to react with other chemicals allows for the creation of new compounds with potential medicinal applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (2,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE is used as a building block for the development of novel therapeutic agents. Its reactivity contributes to the formation of diverse chemical entities that can be further optimized for specific biological targets and therapeutic indications.
Used in Toxicology Studies:
Given the known toxicity of hydrazines, (2,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE may also be employed in toxicological research to understand the mechanisms of action and potential hazards associated with hydrazine derivatives, thereby aiding in the development of safer pharmaceuticals.
Safety Precautions:
It is crucial to handle (2,5-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE with care due to its toxic nature. Proper safety measures, including the use of personal protective equipment, should be taken during its manipulation and storage to prevent exposure and potential harm to human health.

Upstream product

• 95-78-3 2,5-Dimethylaniline 
• 88578-19-2 2,5-dimethyl-benzenediazonium; chloride 
• 89-58-7 mononitro-p-xylene 
• 2493-58-5 2,5-dimethylphenyl tosylate 

Downstream Products

• 861086-41-1 acetic acid-[N'-(2,5-dimethyl-phenyl)-hydrazide] 
• 134724-60-0 1-(2,5-dimethyl-phenyl)-pyrazolidin-3-one 
• 133131-71-2 2-(2,5-dimethyl-phenylhydrazono)-propionic acid ethyl ester 
• 6304-60-5 formic acid-[N'-(2,5-dimethyl-phenyl)-hydrazide] 
• 35774-21-1 2,5-dimethylphenyl azide 
• 900-06-1 (2,5-dimethyl-phenyl)-(2,4-dinitro-phenyl)-diazene 
• 1167442-58-1 7,8-dimethoxy-2-(2,5-dimethylphenyl)-1(2H)-phthalazinone 
• 930909-34-5 2-(2,5-dimethylphenyl)-1(2H)-phthalazinone 
• 92652-15-8 (2,4,7-trimethyl-indol-3-yl)-acetic acid ethyl ester 
• 1375275-51-6 (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(1-ethyl-2,4,7-trimethyl-1H-indol-3-yl)acetamido)-N-methyl-3-phenylpropanamide 
• 1381843-77-1 C₂₅H₂₄N₂ 

Relevant academic research and scientific papers

Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid

N-Aryl derivatives of edaravone were identified as potentially effective small molecule inhibitors of tau and beta-amyloid aggregation in the context of developing disease-modifying therapeutics for Alzheimer's disease (AD). Palladium-catalyzed hydrazine monoarylation protocols were then employed as an expedient means of preparing a focused library of 21 edaravone derivatives featuring varied N-aryl substitution, thereby enabling structure-activity relationship (SAR) studies. On the basis of data obtained from two functional biochemical assays examining the effect of edaravone derivatives on both fibril and oligomer formation, it was determined that derivatives featuring an N-biaryl motif were four-fold more potent than edaravone.

NOVEL ANTIVIRAL COMPOUNDS

The present invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

Novel chromogenic substances and use thereof for the determination of carboxypeptidase activities

The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a compound of formula (I) in which A=(1), (2), (3), (4) or (5). R1. R2=H. —CH3, —CH(CH3)2, —OCH3, —Cl.—CF3,—OCF3,—SCH3, R3=an amino acid group which may be hydrolysed by a carboxypeptidase A and R4=a basic amino acid group.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.