143207-32-3Relevant academic research and scientific papers
Aminolysis of cyclic carbamate analogs of carboxybiotin; metallic catalysis and modelling of carboxytransferase
Botella,Klaebe,Perie,Monnier
, p. 5111 - 5122 (2007/10/02)
Aminolysis of carbamic esters, a model of the intermediate carboxybiotin in enzymatic carboxylations was studied in organic medium in the presence of a divalent cation. This study establishes electrostatic catalysis of aminolysis, the rate determining step of which is the collapse of the tetrahedral intermediate principally by carbon-nitrogen bond breaking. The results also account for the role of the divalent cation present in the carboxytransferase subunit of carboxylases.
