143231-97-4Relevant academic research and scientific papers
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
Nicolaou,Cho, Suk Young,Hughes, Robert,Winssinger, Nicolas,Smethurst, Christian,Labischinski, Harald,Endermann, Rainer
, p. 3798 - 3823 (2007/10/03)
Vancomycin, the prototypical member of the glycopeptide family of antibiotics, is a clinically used antibiotic employed against a variety of drug-resistant bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA). The recent emergence of vancomycin resistance, viewed as a growing threat to public health, prompted us to initiate a program aimed at restoring the potency of this important antibiotic through chemical manipulation of the vancomycin structure. Herein, we describe the development of synthetic technology based on the design of a novel selenium safety catch linker, application of this technology to a solid-phase semisynthesis of vancomycin, and the solid- and solution-phase synthesis of vancomycin libraries. Biological evaluation of these compound libraries led to the identification of a number of in vitro highly potent antibacterial agents effective against vancomycin-resistant bacteria. In addition to aiding these investigations, the solid-phase chemistry described herein is expected to enhance the power of combinatorial chemistry and facilitate chemical biology and medicinal chemistry studies.
Synthesis and Characterization of Liquid Crystalline Monomers and Side-Chain Polymers Containing Diphenyldiacetylene Mesogens
Lu, Yong-Hong,Hsu, Chain-Shu,Wu, Shin-Tson
, p. 1 - 14 (2007/10/02)
Nine unsymmetrically diphenyldiacetylenic monomers were prepared.The phase behavior as well as thermal polymerization of the obtained monomers were characterized by optical polarizing microscopy and DSC measurement.UV absorption, refractive indices and dielectric constants of the monomers were also measured.The olefinic monomers were subjected to undergo hydrosilylation reaction with poly(methylhydrogensiloxane) to form the polysiloxanes.Thermal behavior of the prepared polysiloxanes were studied.
