248588-29-6Relevant academic research and scientific papers
Hierarchical self-assembly of all-organic photovoltaic devices
Huang, Chih-Hao,McClenaghan, Nathan D.,Kuhn, Alexander,Bravic, Georges,Bassani, Dario M.
, p. 2050 - 2059 (2006)
Photovoltaic devices built by a hierarchical self-assembly process using hydrogen-bonding terminated self-assembled monolayers (SAMs) on gold and the combination of a hydrogen-bonding barbituric acid appended fullerene and a complementary melamine termina
CELL IMPERMEABLE COELENTERAZINE ANALOGUES
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Paragraph 0201-0203, (2018/06/15)
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
Hydrogen-bonded CdS nanoparticle assemblies on electrodes for photoelectrochemical applications
Baron, Ronan,Huang, Chih-Hao,Bassani, Dario M.,Onopriyenko, Avital,Zayats, Maya,Willner, Itamar
, p. 4010 - 4015 (2007/10/03)
(Chemical Equation Presented) Trapping the light fantastic-ally! Enhanced photocurrents are observed for hydrogen-bonded gold nanoparticle/CdS nanoparticle arrays associated with a gold electrode surface (see scheme) as a result of charge separation and c
Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
Nicolaou,Cho, Suk Young,Hughes, Robert,Winssinger, Nicolas,Smethurst, Christian,Labischinski, Harald,Endermann, Rainer
, p. 3798 - 3823 (2007/10/03)
Vancomycin, the prototypical member of the glycopeptide family of antibiotics, is a clinically used antibiotic employed against a variety of drug-resistant bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA). The recent emergence of vancomycin resistance, viewed as a growing threat to public health, prompted us to initiate a program aimed at restoring the potency of this important antibiotic through chemical manipulation of the vancomycin structure. Herein, we describe the development of synthetic technology based on the design of a novel selenium safety catch linker, application of this technology to a solid-phase semisynthesis of vancomycin, and the solid- and solution-phase synthesis of vancomycin libraries. Biological evaluation of these compound libraries led to the identification of a number of in vitro highly potent antibacterial agents effective against vancomycin-resistant bacteria. In addition to aiding these investigations, the solid-phase chemistry described herein is expected to enhance the power of combinatorial chemistry and facilitate chemical biology and medicinal chemistry studies.
