143232-23-9Relevant academic research and scientific papers
Sulfur-assisted and 1,8-diazabicy clo [5.4.0] undec-7-ene (DBU)catalyzed cyclization of 2-alkynylanilines for the metal-free synthesis of indole derivatives
Zhou, Hongwei,Zhu, Da,Xing, Yanpeng,Huang, Huafeng
scheme or table, p. 2127 - 2131 (2010/11/04)
A sulfur-assisted and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed cyclization of 2-alkynylanilines for the metal-free synthesis of indole derivatives is reported. As a result of the metal-free process, the ready availability of the starting materials and the simple and convenient operation, the type of reaction presented here has potential utility in organic synthesis. A 10-gram scale preparation may demonstrate the possibility of its application in the environmentally friendly synthesis of indole derivatives.
ARYLTHIOETHER TRYPTAMINE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS
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Page/Page column 15-16, (2010/11/27)
The present invention provides aryithioether tryptamine derivatives of formula (I), useful in treatment of a CNS disorder related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding wi
Inhibitors of HIV reverse transcriptase
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, (2008/06/13)
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
HIV reverse transcriptase
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, (2008/06/13)
Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds or pharmaceutical composition ingredients, whether or not in combination with other
