143232-24-0

Basic information

• Product Name: 1H-Indole, 3-(phenylthio)-2-[(phenylthio)methyl]-
• CAS NO: 143232-24-0
• Molecular Formula: C21H17NS2
• Molecular Weight: 347.505
• Mol File: 143232-24-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 3-(phenylthio)-2-[(phenylthio)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 3-(phenylthio)-2-[(phenylthio)methyl]-(143232-24-0)
• EPA Substance Registry System: 1H-Indole, 3-(phenylthio)-2-[(phenylthio)methyl]-(143232-24-0)

Safety Data

• Hazardous Substances Data: 143232-24-0(Hazardous Substances Data)

Upstream product

• 882-33-7 diphenyldisulfane 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 24621-70-3 2-(hydroxymethyl)indole 
• 143232-23-9 2-phenylthiomethyl-1H-indole 
• 35737-59-8 1,3-bis(phenylthio)propan-2-one 
• 100-63-0 phenylhydrazine 

Downstream Products

• 148404-03-9 (E)-3-(3-Phenylsulfanyl-1H-indol-2-yl)-acrylic acid ethyl ester 
• 148404-05-1 3-Phenylsulfanyl-2-((E)-styryl)-1H-indole 
• 148404-04-0 (E)-4-(3-Phenylsulfanyl-1H-indol-2-yl)-but-3-en-2-one 
• 98055-06-2 2-(2-phenylethyl)-1H-indole 
• 143232-22-8 2-phenylthioindole-2-aldehyde 
• 143246-73-5 2-Phenylsulfinylmethyl-3-phenylthioindole 

Relevant articles and documents

Inhibitors of HIV reverse transcriptase

Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

2-Alkylindoles via Wittig olefination of indole-2-aldehyde

Oxidation of 3-phenylthio-2-phenylthiomethylindole (1) with N-bromosuccinimide affords 3-phenylthioindole-2-aldehyde (3) which undergoes Wittig reaction to give 2-vinyl derivatives (4a-c).The latter afford 2-alkylindoles (5a-c) upon Raney nickel treatment.