143233-25-4Relevant academic research and scientific papers
Synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids from a furyl substituted chiral cyanohydrin
Tromp, Reynier A.,Van Der Hoeven, Michael,Amore, Alessia,Brussee, Johannes,Overhand, Mark,Van Der Marel, Gijs A.,Van Der Gen, Arne
, p. 1645 - 1652 (2003)
A stereoselective chemoenzymatic synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids 6 is described. After the formation of cyanohydrin 2 from 2-furaldehyde in the presence of R-oxynitrilase and subsequent protection, 3 was transformed into fully protected ethanolamines 5. Ozonolysis provided the target compounds in good yields.
