143233-36-7Relevant academic research and scientific papers
Metathesis cascade strategies (ROM-RCM-CM): a DOS approach to skeletally diverse sultams
Jeon, Kyu Ok,Rayabarapu, Dinesh,Rolfe, Alan,Volp, Kelly,Omar, Iman,Hanson, Paul R.
experimental part, p. 4992 - 5000 (2009/10/17)
The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM-RCM-CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived f
Synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids from a furyl substituted chiral cyanohydrin
Tromp, Reynier A.,Van Der Hoeven, Michael,Amore, Alessia,Brussee, Johannes,Overhand, Mark,Van Der Marel, Gijs A.,Van Der Gen, Arne
, p. 1645 - 1652 (2007/10/03)
A stereoselective chemoenzymatic synthesis of Fmoc-protected (2S,3S)-2-hydroxy-3-amino acids 6 is described. After the formation of cyanohydrin 2 from 2-furaldehyde in the presence of R-oxynitrilase and subsequent protection, 3 was transformed into fully protected ethanolamines 5. Ozonolysis provided the target compounds in good yields.
