143234-91-7

Basic information

• Product Name: Benzoic acid (1R,2R)-1-(ethoxycarbonyl-difluoro-methyl)-2,3-dihydroxy-propyl ester
• CAS NO: 143234-91-7
• Molecular Weight: 318.274
• Mol File: 143234-91-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid (1R,2R)-1-(ethoxycarbonyl-difluoro-methyl)-2,3-dihydroxy-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid (1R,2R)-1-(ethoxycarbonyl-difluoro-methyl)-2,3-dihydroxy-propyl ester(143234-91-7)
• EPA Substance Registry System: Benzoic acid (1R,2R)-1-(ethoxycarbonyl-difluoro-methyl)-2,3-dihydroxy-propyl ester(143234-91-7)

Safety Data

• Hazardous Substances Data: 143234-91-7(Hazardous Substances Data)

Upstream product

• 143234-90-6 Benzoic acid (R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-ethoxycarbonyl-2,2-difluoro-ethyl ester 
• 98-88-4 benzoyl chloride 
• 95058-92-7 (erytro) ethyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxy propionate 

Downstream Products

• 122111-07-3 Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester 

Relevant articles and documents

Stereospecific synthesis of 2-deoxy-2,2-difluororibonolactone and its use in the preparation of 2'-deoxy-2',2'-difluoro-β-D-ribofuranosyl pyrimidine nucleosides: The key role of selective crystallization

A stereospecific synthesis of 2'-deoxy-2',2'-difluorocytidine (gemcitabine), a potential anticancer agent, is described. The stereoselectivity was accomplished via two diastereoselective crystallizations, i.e. the crystallization of the key intermediate, difluororibonolactone 2a, and the crystallization of the hydrochloride salt of gemcitabine 16b from the anomeric mixture. Because of the availability of 2a in large quantities, other 2'-deoxy-2',2'-difluoropyrimidine nucleosides such as 2'-deoxy-2',2'-difluorouridine (19) were synthesized for structure-activity relationship studies.