1432346-65-0

Basic information

• Product Name: C₁₈H₁₃BrN₂O₃
• CAS NO: 1432346-65-0
• Molecular Weight: 385.217
• Mol File: 1432346-65-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₃BrN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₃BrN₂O₃(1432346-65-0)
• EPA Substance Registry System: C₁₈H₁₃BrN₂O₃(1432346-65-0)

Safety Data

• Hazardous Substances Data: 1432346-65-0(Hazardous Substances Data)

Upstream product

• 20197-75-5 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 6630-33-7 ortho-bromobenzaldehyde 

Relevant articles and documents

Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors

A series of 1,3,4-oxadiazole derivatives containing 1,4-benzodioxan moiety (7a-7q) have been designed, synthesized and evaluated for their antitumor activity. Most of the synthesized compounds were proved to have potent antitumor activity and low toxicity. Among them, compound 7a showed the most potent biological activity against Human Umbilical Vein Endothelial cells, which was comparable to the positive control. The results of apoptosis and flow cytometry (FCM) demonstrated that compound 7a induce cell apoptosis by the inhibition of MetAP2 pathway. Molecular docking was performed to position compound 7a into MetAP2 binding site in order to explore the potential target.