143236-90-2Relevant academic research and scientific papers
Regio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines
Yu, Lu,Somfai, Peter
supporting information, p. 8551 - 8555 (2019/05/21)
The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of molecules bearing a 1,2-diamine motif.
Highly chemoselective formation of aldehyde enamines under very mild reaction conditions
Belanger, Guillaume,Dore, Michael,Menard, Frederic,Darsigny, Veronique
, p. 7481 - 7484 (2007/10/03)
Although ketone enamines are widely used in organic synthesis, aldehyde enamines are rarely employed due to the limitations of their preparation using known methods (need for acid or base, excess of amine, and/or elevated temperature). We have successfull
Chemically Labile Stannylene-Nitrogen Bonds. The Chemoselective and Stereoselective Synthesis of N,N-Bis(trimethylsilyl)enamines and N,N-Dialkylenamines
Burnell-Curty, Cynthia,Roskamp, Eric J.
, p. 5063 - 5064 (2007/10/02)
The chemoselective reaction of Sn2 with primary aldehydes leads to the stereoselective synthesis of trans-N,N-bis(trimethylsilyl)enamines.More reactive Sn(NR2)2 (R = Et, iPr, or piperidine) can be generated in situ and then treated with aldehydes or ketones to give trans enamines.
