1432371-46-4

Basic information

• Product Name: 2-bromo-N-cyclopropyl-N,5-dimethylbenzamide
• CAS NO: 1432371-46-4
• Molecular Weight: 268.153
• Mol File: 1432371-46-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-cyclopropyl-N,5-dimethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-cyclopropyl-N,5-dimethylbenzamide(1432371-46-4)
• EPA Substance Registry System: 2-bromo-N-cyclopropyl-N,5-dimethylbenzamide(1432371-46-4)

Safety Data

• Hazardous Substances Data: 1432371-46-4(Hazardous Substances Data)

Upstream product

• 409110-31-2 2-bromo-5-methylbenzoyl chloride 
• 6967-82-4 2-bromo-5-methylbenzoic acid 

Relevant articles and documents

Palladium-catalyzed ring-opening of cyclopropyl benzamides: Synthesis of benzo[c]azepine-1-ones via C(sp3)-H functionalization

A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp3)-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination.