1432371-85-1

Basic information

• Product Name: 2-methyl-2,3-dihydro-1H-benzo[c]azepin-1-one
• Synonyms: 2-methyl-2,3-dihydro-1H-benzo[c]azepin-1-one
• CAS NO: 1432371-85-1
• Molecular Weight: 173.214
• Mol File: 1432371-85-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-2,3-dihydro-1H-benzo[c]azepin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2,3-dihydro-1H-benzo[c]azepin-1-one(1432371-85-1)
• EPA Substance Registry System: 2-methyl-2,3-dihydro-1H-benzo[c]azepin-1-one(1432371-85-1)

Safety Data

• Hazardous Substances Data: 1432371-85-1(Hazardous Substances Data)

Upstream product

• 1248615-31-7 2-iodo-N-cyclopropyl-N-methylbenzamide 
• 88-67-5 2-Iodobenzoic acid 
• 88229-19-0 N-Cyclopropyl-2-iodo-benzamide 
• 609-67-6 2-Iodobenzoyl chloride 

Relevant articles and documents

Palladium-catalyzed ring-opening of cyclopropyl benzamides: Synthesis of benzo[c]azepine-1-ones via C(sp3)-H functionalization

A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp3)-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination.