1432435-68-1

Basic information

• Product Name: [Cp₂V(4,7-Ph₂-phen)][OTf]₂
• CAS NO: 1432435-68-1
• Molecular Weight: 512.527
• Mol File: 1432435-68-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [Cp₂V(4,7-Ph₂-phen)][OTf]₂(CAS DataBase Reference)
• NIST Chemistry Reference: [Cp₂V(4,7-Ph₂-phen)][OTf]₂(1432435-68-1)
• EPA Substance Registry System: [Cp₂V(4,7-Ph₂-phen)][OTf]₂(1432435-68-1)

Safety Data

• Hazardous Substances Data: 1432435-68-1(Hazardous Substances Data)

Upstream product

• 12083-48-6 vanadocene dichloride 
• 1662-01-7 bathophenanthroline 
• 2923-28-6 silver trifluoromethanesulfonate 

Relevant articles and documents

Can substitution of chlorides enhance the cytotoxicity of vanadocene dichloride?

A series of vanadocene complexes [Cp′2V(L)][OTf] 2 (Cp′ = η5-C5H5, η5-C5H4Me; L = phen, 5-NO2-phen, 5-NH2-phen, 4,7-Ph2-phen) was prepared and characterized by mass spectrometry and EPR spectroscopy. Structures of two complexes that contain an N,N′-chelating ligand, [(η5-C5H 4Me)2V(phen)][OTf]2·0.5Me2CO and [(η5-C5H5)2V(5-NH 2-phen)][OTf]2, and the triflate intermediate [(η5-C5H5)2V(OTf)2] were further confirmed by X-ray diffraction analysis. The cytotoxicity study has shown that complexes that contain phenanthroline ligands have considerably higher in vitro activity toward human leukemia cells MOLT-4 and HL-60 than their parent dichlorides ([Cp′2VCl2]). The high activity of these complexes coheres with their higher stability in various aqueous media. This study has further shown that substitution of chloride ligands in the vanadocene dichloride has a considerably higher effect on cytotoxicity than expected on the basis of established mechanistic rules. Copyright