1432589-62-2

Upstream product

• 1432589-58-6 C₂₆H₃₈N₂O₃Si 
• 98-59-9 p-toluenesulfonyl chloride 
• 51-35-4 4R-4-hydroxyproline 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 226225-42-9 (2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]pyrrolidine-2-carboxylic acid methyl ester 
• 615582-98-4 (2S,4R)-N-tert-butyloxycarbonyl-4-[(tert-butyldiphenylsilyl)oxy]-2-hydroxymethylpyrrolidine 
• 1432589-52-0 C₂₇H₃₉NO₆SSi 
• 1432589-55-3 C₂₆H₃₆N₄O₃Si 

Downstream Products

• 1432589-07-5 N-(((2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl)methyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

A novel method to access chiral nonnatural 2,4-disubstituted pyrrolidines from aldehydes and nitroolefins only with an α-substituent

A series of α-substituted nitroolefins were employed in organocatalytic asymmetric Michael reactions with aldehydes. γ-Nitro carbonyl products were achieved in good yields (up to 86%) with good stereoselectivities (up to 96% ee and 24 : 1 dr). Reduction of the nitro group followed by intramolecular reductive amination successfully afforded various novel optically active 2,4-disubstituted pyrrolidine compounds.