143261-87-4Relevant academic research and scientific papers
SYNTHESIS OF 1,2,3,4-TETRAHYDROACRIDINE AND 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES AS POTENTIAL ACETYLCHOLINESTERASE INHIBITORS
Gatta, Franco,Giudice, Maria Rosaria Del,Pomponi, Massimo,Marta, Maurizio
, p. 991 - 1004 (2007/10/02)
This paper described the synthesis of 1,3,4,5-tetrahydropyrazoloacridine (2) and 11-amino-1,3,4,5-tetrahydroazepinoquinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazoloacridine (7) obtained in the same manner starting from 3,4-dihydroacridine-1,9-(2H,10H)-dione (6).The corresponding pyrazoloquinoline (20) and isoxazoloquinoline (18) are also reported.The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.
