143262-07-1

Upstream product

• 143262-03-7 N-tosyl-2-(1-isopropylthio-2-methoxyethyl)-6-chloroanilide 
• 77820-58-7 methyl 3-chloroanthranilate 
• 95-51-2 o-chloroaniline 
• 143261-99-8 2-(1-isopropylthio-2-methoxyethyl)-6-chloroaniline 
• 247237-41-8 N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester 
• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 894810-82-3 N-allyl-N-p-toluenesulfonyl-3-chloroanthranilic acid methyl ester 
• 894810-83-4 N-allyl-N-p-toluenesulfonyl-2-chloro-6-(hydroxymethyl)aniline 
• 894810-84-5 N-allyl-N-p-toluenesulfonyl-2-chloro-6-formylaniline 
• 894810-43-6 N-allyl-N-(2-chloro-6-vinyl-phenyl)-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Development of isomerization and cycloisomerization with use of a ruthenium hydride with N-heterocyclic carbene and its application to the synthesis of heterocycles

A pure ruthenium hydride complex with N-heterocyclic carbene (NHC) ligand was efficiently generated from the reaction of a second-generation Grubbs ruthenium catalyst with vinyloxytrimethylsilane and unambiguously characterized. This ruthenium hydride complex showed high catalytic activity for the selective isomerization of terminal olefin and for the cycloisomerization of 1,6-dienes. These reactions of N-allyl-o-vinylaniline lead to novel synthetic methods for heterocycles such as indoles and 3-methylene-2,3-dihydroindoles, which are useful synthons for bioactive natural products. These procedures address an important issue in diversity-oriented synthesis.

SYNTHESIS OF 4-, 5-, 6- AND 7-SUBSTITUTED N-TOSYLINDOLES FROM SUBSTITUTED ANILINES

4-, 5-, 6-, and 7-Substituted N-tosylindoles are prepared from N-tosylanilides, carrying 2-acetoxy-1-(isopropylthio)ethyl group at the ortho position, which can be prepared from substituted anilines and dialkyl sulfide by sigmatropic rearrangement.