1432736-07-6Relevant academic research and scientific papers
A naphthalocyanine based near-infrared photosensitizer: Synthesis and in vitro photodynamic activities
Luan, Liqiang,Ding, Lanlan,Zhang, Weijia,Shi, Jiawei,Yu, Xiaoqiang,Liu, Wei
, p. 3775 - 3779 (2013)
A hydrophilic near-infrared (NIR) photosensitizer featuring a naphthalocyanine core and peripheral carboxylate acid groups was synthesized and characterized. Its photophysical and photochemical properties were studied and compared with phthalocyanine. Due to the extended π-conjugation, both the Q band and fluorescence emit of this naphthalocyanine bathochromically shift to NIR region. It also exhibits superior NIR photodynamic efficiency to phthalocyanine as evidenced by high efficiency in generating singlet oxygen (ΦΔ = 0.66) and in vitro phototoxicity toward Hela human cervical cancer cells. Therefore, this novel naphthalocyanine could potentially be a NIR photosensitizer for photodynamic therapy.
