143294-15-9Relevant academic research and scientific papers
Synthesis of Diribonucleoside Phosphorothioates via Stereospecific Sulfurization of H-Phosphonate Diesters
Almer, H.,Stawinski, J.,Stroemberg, R.,Thelin, M.
, p. 6163 - 6169 (2007/10/02)
Sulfurization of diribonucleoside H-phosphonates with elemental sulfur was found to be a stereospecific reaction.With this finding as the basis, an efficient method for the preparation of stereochemically homogeneous diribonucleoside phosphorothioates has
Solid-phase synthesis of RNA via a silyl-protecting-group strategy
Dreef-Tromp, C. M.,Dam, E. M. A. van,Elst, H. van den,Boogaart, J. E. van den,Marel, G. A. van der,Boom, J. H. van
, p. 378 - 383 (2007/10/02)
Ribonucleoside phosphoramidites have been prepared of which the exocyclic amino functions and 2'-hydroxyl functions are protected with 2-benzoyl groups, respectively.The N-SiOMB/O-TBDMS-blocked nucleosides proved to be suitable building units in a solid-phase synthesis of the RNA-fragment 5'-AGAGUACCU-3' via a phosphite triester approach.
