1433061-46-1Relevant articles and documents
Asymmetric induction via short-lived chiral enolates with a chiral C-O axis
Yoshimura, Tomoyuki,Tomohara, Keisuke,Kawabata, Takeo
, p. 7102 - 7105 (2013/06/27)
A novel method has been developed for the asymmetric cyclization of alkyl aryl ethers. The reactions were assumed to proceed via short-lived chiral enolate intermediates with a chiral C-O axis to give cyclic ethers with tetrasubstituted carbon in up to 99% ee. The half-life of racemization of the chiral enolate intermediate was roughly estimated to be ~1 s at -78 C.