14331-22-7

Usage

Type of compound

Tetrazolo derivative

Usage

Organic synthesis and pharmaceutical research

Potential properties

a. Antioxidant
b. Anti-inflammatory
c. Antimicrobial

Investigated for

Development of new drugs for various diseases

Application

Synthesis of other organic compounds

Role

Reagent in chemical reactions

Unique feature

Structure and potential biological activities

Significance

Valuable for further research and development

InChI:InChI=1/C11H8N4S/c16-11-12-13-14-15(11)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H,12,14,16)

Upstream product

• 13037-43-9 S-methyl-N-(naphthalen-1-yl)carbamodithioate 
• 10320-97-5 N-(naphthalen-1-yl)-1,2,3,4-thiatriazol-5-amine 
• 42135-78-4 4-(1-naphthyl)-3-thiosemicarbazide 
• 551-06-4 1-isothiocyanatonaphthalene 
• 15866-95-2 naphthalen-1-yl-dithiocarbamic acid; ammonium salt 
• 134-32-7 1-amino-naphthalene 

Downstream Products

• 705969-12-6 5-{{3-{(2-chlorophenyl)amino}-2-hydroxypropyl}thio}-1-(1-naphthalenyl)-1H-tetrazole 
• 705969-08-0 5-{{3-(2-chlorophenyl)-3-hydroxypropyl}thio}-1-(1-naphthalenyl)-1H-tetrazole 
• 705969-11-5 5-{{3-(2-chlorophenyl)-2-hydroxypropyl}thio}-1-(1-naphthalenyl)-1H-tetrazole 

Relevant academic research and scientific papers

THERAPEUTIC COMPOUNDS AND USES THEREOF

The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

Mechanism of the zinc-catalyzed addition of azide ion to unsaturated compounds: Synthesis of 5-substituted 1Н-tetrazoles from nitriles and of 1-substituted 1Н-tetrazole-5-thiols from isothiocyanates

The mechanism of the formation of 5-substituted 1H-tetrazoles from organic nitriles and thiocyanates in the presence of NaN3 and ZnCl2 in aliphatic alcohols was studied. The results of this study allowed efficient methods of synthesis of substituted tetrazoles from nitriles, thiocyanates, and isothiocyanates to be proposed.

NEW PROCESS TO MAKE NON-NUCLEOSIDAL REVERSE TRANSCRIPTASE INHIBITORS (NNRTI) FOR THE TREATMENT OF HIV

A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical process can form thiotetrazoles such as 2-((1-(naphthalen-1-yl)-1H-tetrazol-5-yl)thio)-N-(2- nitrophenyl)actetamide that is. a potent NNRTI with nanomolar activity.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID LEVELS

Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Disclosed herein are compounds of formula Ar1-X-W-Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)- N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.