1433193-95-3

Upstream product

• 1433193-94-2 4-(2-aminophenyl)-1-benzyl-3-(2-chlorophenyl)-5,6-dihydropyridin-2(1H)-one 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 1433193-93-1 1-benzyl-3-bromo-4-[2-(tritylamino)phenyl]-5,6-dihydropyridin-2(1H)-one 
• 1433193-92-0 4-(2-aminophenyl)-1-benzyl-3-bromo-5,6-dihydropyridin-2(1H)-one 
• 1433193-91-9 tert-butyl [2-(1-benzyl-6-oxo-1,2,3,6-tetrahydropyridin-4-yl)phenyl]carbamate 
• 1370528-70-3 1-benzyl-6-oxo-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate 
• 70571-31-2 1-benzylpiperidine-2,4-dione 
• 182559-62-2 ethyl 3-[benzyl(3-ethoxy-3-oxopropyl)amino]-3-oxopropanoate 
• 23583-21-3 ethyl-3-benzylamino propionate 

Downstream Products

• 1433193-90-8 1-benzyl-3-(2-chlorophenyl)-4-[2-(4-methoxyphenyliminomethyleneamino)phenyl]-5,6-dihydropyridin-2(1H)-one 

Relevant academic research and scientific papers

Synthetic study of perophoramidine: Construction of pentacyclic core structure via SmI2-mediated reductive cyclization

An intramolecular SmI2-mediated reductive cyclization of carbodiimides and unsaturated lactams was applied to functionalized substrates bearing tetrasubstituted olefins. The reaction afforded arylated spiro-2-iminoindolines in high yield. Although the stereochemistry of the product was different from the desired one, the optimized palladium-catalyzed aryl amidination realized the isomerization and C-N bond formation in a single step and resulted in efficient construction of pentacyclic core of perophoramidine synthetically equivalent to the Rainier's intermediate.